Scope: Addressing the limitations of animal testing and societal demand for alternative methodologies, this call focuses on enhancing the use of NAMs in regulatory safety and efficacy testing of chemicals and pharmaceuticals. Proposals should bridge the gap between NAM developers, users, and European regulators, facilitating the integration of NAMs into legal frameworks and decision-making processes.

Key Activities: Proposals should:

· Develop technical and regulatory readiness criteria for NAMs.

· Support technology transfer to bring NAMs to market.

· Standardize NAMs through international organizations such as OECD, CEN, ISO, ICH, VICH.

· Provide technical training for Contract Research Organizations (CROs) using NAMs for regulatory purposes.

· Promote dialogue among companies, regulatory bodies (e.g., ECHA, EMA, EFSA), and Member States authorities on integrating and interpreting NAM data.

· Identify and propose changes to EU legislation to overcome obstacles and facilitate NAM use.

Collaboration: Encourages collaboration with existing initiatives like the Partnership for the Assessment of Risks from Chemicals (PARC) and the ASPIS cluster. Proposals should consider involving the JRC to leverage its expertise in facilitating the regulatory application of NAMs.

Aim: This funding opportunity seeks to modernize regulatory testing frameworks, moving towards a more ethical, efficient, and human-relevant approach. It aims to establish a solid foundation for the widespread acceptance and use of NAMs, ultimately benefiting public health, the environment, and animal welfare.

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